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KMID : 0923620150150020058
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Immune Network
2015 Volume.15 No. 2 p.58 ~ p.65
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Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells
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:Kim Ji-Sung
:Kim Yong-Guk/:Pyo Min-ji/:Lee Hong-Kyung/:Hong Jin-Tae/:Kim Young-soo/:Han Sang-Bae
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Abstract
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Melanoma is the most aggressive skin cancer and its incidence is gradually increasing worldwide. Patients with metastatic melanoma have a very poor prognosis (estimated 5-year survival rate of <16%). In the last few years, several drugs have been approved for malignant melanoma, such as tyrosine kinase inhibitors and immune checkpoint blockades. Although new therapeutic agents have improved progression-free and overall survival, their use is limited by drug resistance and drug-related toxicity. At the same time, adoptive cell therapy of metastatic melanoma with tumor-infiltrating lymphocytes has shown promising results in preclinical and clinical studies. In this review, we summarize the currently available drugs for treatment of malignant melanoma. In addition, we suggest cytokine-induced killer (CIK) cells as another candidate approach for adoptive cell therapy of melanoma. Our preclinical study and several previous studies have shown that CIK cells have potent anti-tumor activity against melanomas in vitro and in an in vivo human tumor xenograft model without any toxicity.
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KEYWORD
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Melanoma, Preclinical study, Cytokine-induced killer cells
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